KMID : 0381120100320040353
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Genes and Genomics 2010 Volume.32 No. 4 p.353 ~ p.359
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A preliminary study on the origin of Koreans based on Y-STR variation
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Kim Soon-Hee
Chun Byung-Won Jung Jong-Woo Kemp Brian M. Kwak Kyoung-Don Cho Nam-Soo Kim Jong-Jin Han Myun-Soo Kim Won
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Abstract
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To investigate the origin of Koreans, we examined the 12-locus Y-chromosome short tandem repeat (Y-STR) variation in a sample of 310 unrelated males from three localities (Gochang, Andong and Geoje) in Korea and statistically analyzed the previously published four Y-STR databases (n = 1655) of Korean population. The median joining network of 9-locus Y-STR haplotypes inferred as haplogroup O2b-SRY+465 showed a ¡°star cluster¡± indicative of a population expansion from a centrally positioned haplotype. The central haplotype in the ¡°star cluster¡± was the most frequently occurring Y-STR haplotype among the Korean male gene pool (6%, 127 of 1965, 10,14,12,13,14,16,13,13,23, for loci DYS391, DYS389I, DYS439, DYS438, DYS437, DYS19, DYS392, DYS393, and DYS390), which was shared among all seven datasets. Based on the ¡°star cluster¡± pattern from both our data (41%, 128 of 310) and those previously published (34%, 563 of 1655), we suggest that the most frequent Y-STR haplotype among the Korean male gene pool seems to be the Korean modal (ancestral) haplotype. Further study with additional Y-STR and Y-SNP data of the east Asian populations as well as Korean population are needed to providing a genetic clue for the ¡°star cluster¡± (O2b-SRY+465) associated with the ethnohistoric events of the Koreans.
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KEYWORD
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Y-STRs, Korean population, Origin of Koreans, Star cluster, Modal (ancestral) haplotype
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